The comparisons of HDAC5 expression between anaplastic oligoastrocytoma (n = 6), anaplastic oligodendroglioma (n = 3), GBM (n = 27), and normal (n = 4) exposed a 2.10-fold (p = 4.64E-05), 2.44-fold (p = 0.003), 2.38-fold (p = 1.46E-07) decrease, respectively (Bredel et al., 2005). This evidence concerns the gene HDAC5 and glioblastoma.