Since the prognosis of glioma mainly depends on the pathological grade and genetic mutations, among which isocitrate dehydrogenase 1 (IDH1) and 1p/19q status represented primary concern, further investigation was conducted in an attempt to research relations between HDAC family and IDH1 and 1p/19q based on the CGGA glioma cohort. The gene discussed is IDH1; the disease is central nervous system cancer.