HDAC5 mRNA level in GBM (n = 81) was down-regulated with a FC of 2.22 in Sun’s 2006 study (p = 6.80E-20), and a fold change of 2.74 in the GBM cohort (n = 542) from TCGA (p = 3.08E-08) (Sun et al., 2006). This evidence concerns the gene HDAC5 and glioblastoma.