Specifically, the mRNA level of HDAC1 (p = 1.25e−13), HDAC3 (p = 2.51e−09), HDAC7 (p = 1.43e−19), and HDAC8 (p = 3.48e−10) showed an increasing trend with glioma grade progressing (Figures 3A,C). Here, HDAC8 is linked to central nervous system cancer.