TGFB1 and Hepatic fibrosis: The TGF-β1 signaling pathway plays a key role in cell proliferation and differentiation, and extensive studies have shown that inhibition of this signaling pathway reduces the degree of liver fibrosis (Inagaki and Okazaki, 2007; Verrecchia and Mauviel, 2007; Lichtman et al., 2016).