The CLPTM1L (cleft lip and palate transmembrane protein 1) gene, also known as CRR9, is a LC risk candidate gene that was found to be overexpressed in human lung tumor cell lines and lung tumors (James et al., 2012; Ni et al., 2012). The gene discussed is CLPTM1L; the disease is laryngotracheoesophageal cleft.