PPARGC1A and neoplasm: For example, based on tumor cell lines, the anti-proliferative and pro-apoptotic activities of resveratrol include the ability to modulate the expression of pro-oncogenic and tumor suppressor microRNAs (miRNAs), peroxisome proliferator-activated receptor (PPAR), nuclear factor-kappa B (NF-kB), nuclear respiratory factor- (NRF-) 1 and 2, gamma coactivator 1 alpha (PGC-1α) and p53 transcription factors, and transforming growth factor β (TGF-β) signaling pathways, to exert pro-di?erentiation abilities and act in synergy with conventional anticancer drugs (Vervandier-Fasseur and Latruffe, 2019).