MAPK3 and cancer: In cellular regulative mechanism, resveratrol has revealed to be effective to induce apoptosis by binding with αvβ3 integrin, to activate extracellular signal-regulated kinase (ERK)1/2 via MAPK-kinase [mitogen-activated extracellular signal-regulated kinase (MEK1/2)] (Elshaer et al., 2018), an essential protein in the interaction of cancer cells.