Similarly, the effect of resveratrol in PC was also explored to elucidate the mode of action of this compound, being observed a critical downregulation of metastasis-associated protein (MTA1), which is highly related to the repressive chromatin involved with cancer progression and metastasis in three PC cell lines (Figure 3B) (Kai et al., 2010). The gene discussed is LYPD5; the disease is pachyonychia congenita.