NFE2L2 and head and neck cancer: Specifically, in head and neck cancer, a deficient autophagy triggers p62 accumulation (an autophagy adapter protein) (Tian et al., 2019), with resveratrol being able to stimulate autophagy and accelerate the p62 degradation, in addition to inhibiting the nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway.