Tf-targeted resveratrol-loaded liposomes (Tf-resveratrol-L) increased cytotoxicity and induced higher levels of apoptosis accompanied by a boost in caspases 3/7 activity in glioblastoma (GBM) cells when compared to free resveratrol or resveratrol-PEGylated liposomes. Here, TF is linked to glioblastoma.