In this respect, resveratrol has shown to be able to decrease the expression levels of MMP-2 and MMP-9, fibronectin, α-smooth muscle actin (α-SMA), phosphorylated phosphatidylinositol 3-kinase (P-PI3K), phosphorylated-Akt (P-Akt), mothers against decapentaplegic homolog (Smad)2, Smad3, phosphorylated (P)-Smad, P-Smad3, vimentin, Snail1, and Slug while decreasing E-cadherin levels in MDA-MB-231 human breast cancer cells (Sun et al., 2019). This evidence concerns the gene SMAD3 and breast cancer.