The Th17/IL-17 axis may be the bridge (or part of it) between LES and other organs comorbidities and outcomes (241, 242), such as cardiovascular disease because it is known to promote endothelial activation (233, 234), prothrombotic states (167, 168), hypertension (166, 177), and atherogenesis (207, 243, 244); and osteoporosis because it is known to increase bone catabolic activity (245). This evidence concerns the gene IL17A and hypertensive disorder.