The SNPs of IL-17 rs2275913 were significantly more frequent among JSLE patients than HC (21 vs. 7%, OR: 3.8; and 37 vs. 29%, OR: 1.4, for A/A genotype and A allele, respectively; p < 0.003 for both). No significant difference was found for other SNPs. Patients carrying the IL-17 SNPs rs2275913 were more likely to develop LN (OR: 5.64 and OR = 2.73, for A/A genotype and A allele, respectively). This evidence concerns the gene IL17A and lobular neoplasia.