In another study, with measurement of urinary IL-17 (uIL-17), the levels of uIL-17 were significantly higher in the severe LN than in the control group (P < 0.05); and increased with disease severity seen in biopsy (mean ± SD: 43.96 ± 24.04, 55.69 ± 33.21, and 124.02 ± 256.74 pg/ml; for HC, class I-II, and class III-IV LN, respectively) (55). This evidence concerns the gene IL17A and lobular neoplasia.