IL17A and lobular neoplasia: In LN patients, the levels of IgG, anti-dsDNA, and IL-6 were higher in PBMC supernatants under IL-17 stimulation than in a normal culture medium. The increase in IgG, anti-dsDNA, and IL-6 levels, induced by IL-17, was dose-dependent and could be completely blocked by IL-17 monoclonal antibody and partially blocked by dexamethasone. During stimulation with IL-17, IL-6 mRNA levels were higher in LN patients than in HC (mean ± SD: 3.21 ± 0.24 vs. 1.30 ± 0.14, P < 0.05).