In the Aβ25–35-induced AD rats, both enhanced expression of GRP78, CHOP, caspase-3, BAX and attenuated expression of BCL-2 were observed in the hippocampal CA1 region (Hippo) and prefrontal cortical (PFC), while the situation was reversed by treatment with resveratrol (a polyphenolic stilbenoid, present in grapes, mulberries, peanuts and other plants; Malaguarnera, 2019) and crocin (a non-tetraquinone pigment extracted from Crocus sativus L.; Shafahi et al., 2018). Here, HSPA5 is linked to Alzheimer disease.