ARHGEF38 and benign prostatic hyperplasia: Liu et al. (2020) found that ARHGEF38 is significantly overexpressed in PCa compared to benign prostate hyperplasia, especially in high-grade prostate cancer. In addition, compared to tissues without lymph node metastasis, ARHGEF38 protein presents a much higher expression in PCa tissues with lymph node metastasis. These results suggest that ARHGEF38 may promote PCa migration and metastasis, thereby contribute to PCa progression (Liu et al., 2020).