Neuropilin and tolloid-like 2 (NETO2), a member of the subfamily containing CUB and LDLa domains, has recently been reported to be upregulated in different types of solid tumors, such as colorectal cancer (Hu et al., 2015), pancreatic cancer (Li et al., 2019), and hepatocellular carcinoma (Villa et al., 2016). The gene discussed is NETO2; the disease is colorectal cancer.