Neuropilin and tolloid-like 2 (NETO2), a member of the subfamily containing CUB and LDLa domains, has recently been reported to be upregulated in different types of solid tumors, such as colorectal cancer (Hu et al., 2015), pancreatic cancer (Li et al., 2019), and hepatocellular carcinoma (Villa et al., 2016). Here, NETO2 is linked to hepatocellular carcinoma.