CAMKMT and sarcoma: In this work, we have studied the molecular base by which KMT inhibitors, chaetocin and tazemetostat, impair DDR (32, 52) by mimicking a DNA repair defect, which would allow their use as DNA damage sensitizers (53, 54) and become candidates for novel synthetic lethality strategies in sarcomas cells treated with either ionizing radiation (IR) (Lee et al., 2013) or doxorubicin (Maurel et al., 2009; D’Ambrosio et al., 2020).