Cardiac-specific TMBIM1 KO causes a pathological cardiac hypertrophy by lack of lysosomal degradation of the activated proinflammatory and prohypertrophy factor Toll-like receptor 4 (TRL4; Deng et al., 2018), while TMBIM1 overexpression in hepatocytes of mice inhibited high-fat diet–induced insulin resistance, hepatic steatosis and inflammation by promoting lysosomal degradation of TRL4 (Zhao et al., 2017). Here, TMBIM1 is linked to fatty liver disease.