Furthermore, among the five circRNAs originated from GLIS3 (circGLIS3, hsa_circ_0004822, hsa_circ_0138784, hsa_circ_0006370, and hsa_circ_0086248) measured by microarray analysis, the circGLIS3 expression level in glioma was increased most (Figure 1C), similarly with the GLIS3 mRNA expression level according to Song et al. (2016), indicating that circGLIS3 might be specifically regulated in HGG. This evidence concerns the gene GLIS3 and central nervous system cancer.