MAPK signaling and JAK-STAT signaling pathways have been shown to have vital roles in BLCA progression and might be connected with TNFAIP8L3 activation (Huang et al., 2020; Lei et al., 2020), but the mechanisms connecting TNFAIP8L3 and these two pathways remain unclear. The gene discussed is SOAT1; the disease is bladder transitional cell carcinoma.