However, in our study of BLCA, although we revealed that the methylation and expression change of APC influenced BLCA progression through Wnt/β-catenin signaling and ErbB receptor pathways, suppression of APC expression by DNA methylation was associated with good disease progression so that cases with poor prognosis had relatively high expression and low methylation level of APC. Here, APC is linked to bladder transitional cell carcinoma.