KRT14 and epidermolysis bullosa simplex: We began with the point mutation at the “hotspot” R125 located in the α-helical 1A domain of keratin 14 (KRT14, type I IF family), where substitution of R125 by histidine leads to the occurrence of a monogenic disease, specifically the Dowling-Meara type of epidermolysis bullosa simplex (EBS) (Coulombe et al., 1991) (Figure 1C).