After that, 3 cases of spastic paraplegia were found in patients (No. 2, 22, and 26) with responsible genes including (HACE1, ATL1, AP4M1), respectively, and two cases of cerebellar ataxia in patients (No. 14 and 43), whose responsible genes were SNX14, TDP2, respectively. The gene discussed is TDP2; the disease is Spastic paraplegia.