Myrislignan is a main active ingredient of nutmeg exhibiting various bioactivities, such as inducing apoptosis and cell cycle arrest in A549 cells (Lu et al., 2017), activating the AMPK enzyme and exerting anti-obesity effect (Nguyen et al., 2010), inhibiting the activation of NF-kB signalling pathway, reducing the inflammatory response of macrophages induced by lipopolysaccharide, and protecting the liver from thioacetamide injury (Jin et al., 2012; Yang et al., 2018). The gene discussed is NFKB1; the disease is obesity due to melanocortin 4 receptor deficiency.