The t (9,11) AML presents in 3-5% of AML events, generated by the fusion of mixed lineage leukemia (MLL) gene on 11q23 and mixed lineage leukemia translocated to chromosome 3 (MLLT3) gene on 9p22, producing the fusion protein MLL-MLLT3 (143, 144). The gene discussed is MLLT3; the disease is acute myeloid leukemia.