AML is frequently associated with chromatin rearrangement, including translocation and inversion, which generate oncogenic fusion proteins, among of which four most common chimeric proteins should be paid more attention, including AML1-ETO, PML-RARα, CBFβ-MYH11, and MLL-MLLT3 (4, 6, 32–34). Here, KMT2A is linked to acute myeloid leukemia.