AML is frequently associated with chromatin rearrangement, including translocation and inversion, which generate oncogenic fusion proteins, among of which four most common chimeric proteins should be paid more attention, including AML1-ETO, PML-RARα, CBFβ-MYH11, and MLL-MLLT3 (4, 6, 32–34). The gene discussed is MLLT3; the disease is acute myeloid leukemia.