TNF and central nervous system cancer: In the high-risk group, we discovered that a total of six gene sets were significantly enriched in tumor-related pathways, including inflammatory response, interleukin (IL)2/signal transducer and activator of transcription (STAT) 5 signaling and tumor necrosis factor α (TNFα) signaling via nuclear factor-κB (NFκB) were closely associated with tumorigenesis and malignant phenotypes such as migration and invasion of glioma (Figures 7A–C).