Based on the available evidence, CD81 and CD82, and TSPAN6 can serve as cancer suppressors, while CD151, TSPAN1, and TSPAN8 act as cancer promoters in the diagnosis and prognosis of HCC patients (50, 68, 78, 86, 87, 103–105) (Tables 2 and 3). The gene discussed is CD81; the disease is hepatocellular carcinoma.