TF and glaucoma: The earliest reports on the biologic role and function of the FOXC1 TF implicated it in abnormal pathologic conditions like glaucoma (16–23), congenital hydrocephalus (24), congenital renal defects (25, 26), congenital heart defects (21, 27–29) and Axenfeld-Rieger Syndrome (21, 30, 31), a congenital disorder characterized by glaucoma and congenital heart defects.