FOXC1 and colorectal carcinoma: Li and coworkers investigated the role of FOXC1 in regulating glycolysis in CRC cells and found that knockdown of FOXC1 expression in LoVo and RKO cells in vitro markedly reduced glucose uptake and lactate production, while ectopic expression of FOXC1 in HT29 and SW480 cells increased glucose consumption and lactate production.