Among them, the effect of I-BET151 on BRD9 may be indirect because BRD9 and BRD4 form a complex.I-BET151 selectively inhibits leukemia mouse models and mixed-lineage leukemia (MLL) primary patient samples, and its half-life is significantly longer than that of similar BET inhibitors (JQ1, I-BET762) (7). This evidence concerns the gene BRD4 and leukemia.