I-BET151 can promote TMZ-mediated inhibition of glioma proliferation, invasion, and migration, enhance the oxidative stress induced by TMZ, and restore susceptibility of glioma cells to TMZ, all of which may be related to the I-BET151-induced expression of the p53-upregulated modulator of apoptosis (PUMA) (92). Here, TP53 is linked to central nervous system cancer.