NRAS and melanoma: The efficacy of I-BET151 is not identical across different melanoma cell lines; the NRAS mutant cell line (Mel-RM) and the NRAS/BRAF wild-type (Me1007) line are the most susceptible cell lines, whereas the NRAS mutant/BRAF wild-type (Mel-JD) line and the NRAS wild-type/BRAF mutant cell lines (SK-Mel-28, Mel-RMU) are relatively insensitive (50).