Furthermore, in melanoma, I-BET151 also inhibits the production of cytokines and chemokines, such as interleukin (IL)-1α, vascular endothelial growth factor C (VEGFC), IL-6, and IL-8, and its effect on NF-κB is mainly mediated via BRD2 (4). The gene discussed is CXCL8; the disease is melanoma.