Monocytes of patients with myeloma easily differentiate into osteoclasts because NF-κB signaling is activated in monocytes by the receptor agonist of NF-κB ligand (RANKL), leading to IκB-α degradation and RelA/P65 nuclear translocation, both of which promote osteoclast generation. This evidence concerns the gene NFKB1 and plasma cell myeloma.