In other studies, higher expression of four circRNAs could predict poor prognosis of HCC patients by KM analysis, including circRNA-SORE, circMET, SCD-circRNA 2, circASAP1 (38, 43, 79, 84); in addition, HCC patients with high expression of circRNA-SORE have poor recurrence-free survival (RFS), so did SCD-circRNA 2. The gene discussed is SCD; the disease is hepatocellular carcinoma.