Highly expressed circMA T2B acts as a sponge of miR-338-3p and inhibits its transcriptional activity, thereby increasing the expression of the target gene kinesin family member C1 (KIFC1), activating the PI3K/AKT/mTOR signaling pathway and upregulating the expression of pyruvate kinase M2 (PKM2), subsequently promoting glycolysis and malignant phenotypes of HCC cells under hypoxic conditions (87). The gene discussed is MTOR; the disease is hepatocellular carcinoma.