For example, circSEPT9 regulated by E2F transcription factor 1 (E2F1) and eukaryotic translation initiation factor 4A3 (EIF4A3) pushes the cancerous derivation of triple-negative breast cancer through the circSEPT9/miR-637/Leukemia Inhibitory Factor (LIF) axis (29). This evidence concerns the gene E2F1 and triple-negative breast carcinoma.