Highly expressed circMA T2B acts as a sponge of miR-338-3p and inhibits its transcriptional activity, thereby increasing the expression of the target gene kinesin family member C1 (KIFC1), activating the PI3K/AKT/mTOR signaling pathway and upregulating the expression of pyruvate kinase M2 (PKM2), subsequently promoting glycolysis and malignant phenotypes of HCC cells under hypoxic conditions (87). Here, AKT1 is linked to hepatocellular carcinoma.