In HCC tissues, nine upregulated circRNAs, namely, circRASGRF2, circBACH1, circFN1, circ-LRIG3, circTCF4.85, hsa_circ_0016788, hsa_circ_0005075, hsa_circ_0128298, circ-CDYL (36, 39, 49, 56, 57, 85, 93–95), constitute potential diagnostic biomarkers in HCC. This evidence concerns the gene LRIG3 and hepatocellular carcinoma.