Through binding to the 3’untranslated region (UTR) of stearoyl-CoA desaturase (SCD) mRNA, RNA binding motif protein 3 (RBM3) increases the production of SCD-circRNA 2, which enhances the phosphorylation of extracellular regulated protein kinase (ERK) and promotes the proliferation of HCC cells (38). This evidence concerns the gene RBM3 and hepatocellular carcinoma.