NFATc3 and circNFATC3 can synergistically interfere with the phosphorylation of the c-Jun NK2-terminal kinase (JNK)/c-jun/serine/threonine kinase (AKT)/mechanistic target of rapamycin kinase (mTOR) cascade to inhibit the progression of HCC, while overexpressed circNFATC3 can inhibit the proliferation of HCC cells, inducing cell apoptosis and weakening the ability of invasion and migration; meanwhile, the size and weight of xenografts in the overexpression group were significantly reduced than those in the knockdown group, and the lung metastasis effect was inhibited (66). Here, MAPK8 is linked to hepatocellular carcinoma.