CircTRIM 33-12 acts as ceRNA and upregulates tet methylcytosine dioxygenase 1 (TET1) expression by competitively binding miR-191, promoting the expression of tumor-suppressor genes [WWC family member 3 (WWC3), tumor protein p53 nuclear protein 1 (TP53INP1), UL16 binding protein 1 (ULBP1), jumonji C domain containing hiatone demethylase 1 homolog D (JHDM1D)] in HCC cells, and reducing 5-hydroxymethylcytosine (5hmC) content, subsequently inhibiting the proliferation and metastasis of HCC cells and inducing immune evasion (80). This evidence concerns the gene WWC3 and hepatocellular carcinoma.