By releasing the tumor-suppressor genes miR-182 and miR-184, circ-102 and circ-166 reduce the expression of downstream target genes FOXO3a, MTSS I-BAR domain containing 1 (MTSS1), and SRY-box transcription factor 7 (SOX7), as well as increasing the levels of c-myc protein and Rb phosphorylation, thereby inhibiting the proliferation and invasion of HCC cells (64). The gene discussed is MTSS1; the disease is neoplasm.