RTKN2 and neoplasm: Hsa_circ_104348 can act as a ceRNA of miR-187-3p, blocking its binding to the downstream target gene rhotekin 2 (RTKN2) to achieve the same trend expression of RTKN2 and hsa_circ_104348, and further activating the Wnt/β-catenin pathway, thereby affecting tumor cell proliferation, invasion, metastasis, and anti-apoptosis ability (52).