GLI2 and hepatocellular carcinoma: Further studies have shown that circZNF609 activates the Hedgehog pathway by inhibiting the expression of miR-15a-5p/15b-5p and upregulating the expression of GLI family zinc finger 2 (GLI2), a downstream target of miR-15a-5p/15b-5p, thereby enhancing proliferation, metastasis, and stemness of HCC cells (89).