Single-cell transcriptomics uncovered a gene signature in glioma composed by immune effector molecules and inhibitory feedback mechanisms (genes such as Ifn-γ, Ctla-4, Pdcd1, IL-10, Tgf-β1 or Ido1) that lead to the reprogramming of T cells subsets that become unable to target the cancer cells (32). Here, IL10 is linked to glioma.