In summary, current frontline standard of care systemic therapy options for R/M HNSCC of the oral cavity, oropharynx, larynx, and hypopharynx include pembrolizumab monotherapy or platinum/5FU plus pembrolizumab for PD-L1 expressers by CPS or platinum/5FU plus pembrolizumab for all patients. The gene discussed is CD274; the disease is head and neck squamous cell carcinoma.