In addition to the effector T cell tumor interface, antitumor immunity can be induced by blockade of the PD-L1:PD-1 pathway on dendritic cells, resulting in increased CD8-positive T cell infiltration of the tumor and suppression of the inhibitory ability of Tregs either directly or indirectly through augmentation of CTL proliferation (41, 42). Here, CD8A is linked to neoplasm.