After initial phase II trials with durvalumab in PD-L1 high (HAWK) and durvalumab, durvalumab plus tremelimumab, or tremelimumab alone in PD-L1 low patients (CONDOR), the phase III EAGLE trial was initiated and randomized platinum failure R/M HNSCC patients to durvalumab plus tremelimumab, durvalumab monotherapy, or investigator choice standard of care chemotherapy. Here, CD274 is linked to head and neck squamous cell carcinoma.