HK2 and central nervous system cancer: 3-Bromopyruvate (3-BrPA), a small molecule analog to lactate, is a potent inhibitor of HK2 and not only induces the cytotoxic effects of chloroethylnitrosoureas and reduces the synthesis of biomacromolecules required for DNA repair in gliomas (80) but also promotes cisplatin sensitivity in non-small-cell lung cancer overexpressing tripartite motif-containing 59 (TRIM 59), which results in a high glycolysis rate and cisplatin resistance via the regulation of phosphatase and tensin homolog deleted on chromosome ten (PTEN)/AKT/HK2 (81).