Recently, more and more studies have proven that while being the energy source of cancer cells, glycolysis is also involved in the activation of oncogenes such as phosphatidylinositol 3-kinase (PI3K) and hypoxia inducible factor-1 alpha (HIF-1A) shift in the tumor microenvironment such as hypoxia and acidosis (7–10). This evidence concerns the gene HIF1A and neoplasm.