AKT1 and colorectal cancer: The overexpression of Helicobacter pylori-secreted Cytotoxin-associated gene A protein contributes to 5-FU resistance by enhancing glycolysis in gastric cancer via the activation of the AKT pathway (180); Copines-1 enhances oxaliplatin resistance of colorectal cancer cells by activating the AKT/GLUT1/HK2 signaling pathway (181).