(84) found that miR-1246 in the exosomes of glioma cells in hypoxia bound to the 3′ end of the mRNA of human telomere repeat binding factor 2 interacting protein (TERF2IP) gene and inhibited its expression though activating STAT3 signal pathway and inhibiting NF-κB signal pathway, which eventually induced M2 macrophage polarization and promoted the formation of the immunosuppressive tumor microenvironment (Table 1). The gene discussed is STAT3; the disease is central nervous system cancer.