In the present study, the proportion of IDH mutation cases was noticeably higher in NRG compared with RG [31/42(73.8%) vs 14/22(63.6%)]; however, the statistic results showed that there was not a significant difference between NRG and RG (Table 2), which indicated that there might not be a link between the IDHI mutation and tumor recurrence; nevertheless, due to the limitation of our relatively small sample size, it still needs a big sample for further verification. The gene discussed is IDH1; the disease is neoplasm.