NUCB2 and gestational diabetes: Nesfatin-1, which is directly related to appetite, might play a role in regulating body weight in pregnant women, albeit the effects of nesfatin-1 on the underlying pathogenesis of GDM are not entirely figured out. Given that individuals with high body weight are predisposed to GDM, it is an expected result that nesfatin-1 concentrations are found to be lower among pregnant women with GDM.