In general, AGD influenced the mRNA expression of examined genes involved in immune and inflammatory response (TNF-α, iNOS, IL4-13b, GATA-3, IL-1β, p53, COX2 and PGE2-EP4), and most of these genes were either upregulated or downregulated at 21 dpc compared to 0 dpc and 28 dpc. The gene discussed is NOS2; the disease is argyrophilic grain disease.