The former includes tumor size and multiplicity, presence or absence of portal vein invasion by tumor (PVT), degree of tumor differentiation, serum levels of serum alpha-fetoprotein [1–4] and an immature form of prothrombin called desgamma carboxy prothrombin or DCP [5], which in turn is associated with increased incidence of PVT [6]. The gene discussed is F2; the disease is neoplasm.