Moreover, levofloxacin effectively targeted breast cancer cells and acted synergistically with 5-fluorouracil through inhibiting mitochondrial biogenesis and was accompanied by the deactivation of PI3K/PKB/mammalian target of rapamycin (mTOR) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathways [118]. This evidence concerns the gene MTOR and breast carcinoma.