In contrast, different results were observed in a much larger cohort study named the CRIC (Chronic Renal Insufficiency Cohort), which performed in a cohort of 1501 patients with a mean eGFR of 47 mL/min/1.73 m2 and showed that there are no associations between FGF23 levels and the prevalence of coronary artery calcification [64]. The gene discussed is FGF23; the disease is chronic kidney disease.