SOD1 and major depressive disorder: It was found that the effects of puerarin on depression-like behavior and neuropathic pain in C57BL mice with nerve injury (SNI) can restore the consumption of reduced glutathione (GSH) and superoxide dismutase (SOD) induced by SNI and induce the expression of brain-derived neurotrophic factor (BDNF) rapidly and continuously thus effectively reducing depression and chronic pain in SNI mice [34].