COG2 and neoplasm: Similarly, high mRNA expression of 5 of all COG isoforms (COG2, COG3, COG5, COG6, COG7, and COG8) was also correlated with favourable OS of KIRC patients with tumour grade 2, grade 3, and grade 4, while patients with low mRNA expression of COG4 showed higher survival rate (Figure 7).