Similarly, Michalska and colleagues 20 conducted an experiment with 700 ovarian carcinoma patients and 700 healthy subjects, and revealed a significant increase of the XRCC2 188Arg/His and 188His/His heterozygote frequencies in ovarian carcinomas than that in healthy subjects, which indicated that XRCC2 Arg188His polymorphisms might be positively linked to ovarian malignances in Polish population, especially in grade I ovarian carcinomas. This evidence concerns the gene XRCC2 and ovarian carcinoma.