Consistence with our results, the recent study utilized laser capture microdissection (LCM) method to confirm that the expression of NNMT in the CAFs is significantly higher than that in tumor cells and leads to ovarian cancer progression by metabolic regulation of histone methylation, which causes transcriptional and epigenetic changes in stromal cells to promote cancer cell migration and metastasis 18. This evidence concerns the gene NNMT and ovarian carcinoma.