UBA2 and colorectal carcinoma: These achieved data suggested that the luciferase activity of the UBA2-WT-3'-UTR plasmid in the CRC cell line was clearly decreased by miR-133a upregulation, and was obviously raised by miR-133a downregulation, however, the luciferase activity of UBA2-MUT-3'-UTR did not change (Figure 3G), indicative of the direct correlation between miR-133a and the 3'UTR of UBA2 mRNA.