Compared with cells in DDP treatment alone, PGPIPN significantly reduced the mRNA level of HSF1 and HSP70 in both human ovarian cancer cell lines and primary ovarian cancer cell, which displayed a dose-dependent, and the effect of drug-resistant cells (SKOV3/DDP, COC1/DDP) were significantly better than that of sensitive cells (SKOV3, COC1) (Figure 5). The gene discussed is HSF1; the disease is ovarian cancer.