IP6, originating as a natural ingredient of whole grains, inhibited CCN2-Wnt/β-catenin signaling and downregulated ABCG1 expression levels in HCC cells, and therefore indicating CCN2-LRP6-Wnt/β-catenin-ABCG1 signaling was one of the mechanisms of IP6 treatment in HCC. This evidence concerns the gene ABCG1 and hepatocellular carcinoma.