The specific structure of the tribbles family allows the performance of specific biological functions, such as inhibiting embryo mitosis and regulating the cell cycle (TRIB1-3) 11, 12 , inducing myeloid leukemia (TRIB1-3) 13-15, inhibiting vascular smooth muscle migration (TRIB1 and TRIB3) 16, 17, and inducing Alzheimer's disease (TRIB3) 18. Here, TRIB3 is linked to early-onset autosomal dominant Alzheimer disease.