Documented clinical studies have verified that integrated Chinese and Western medicine has good effects on COPD, such as decreasing the frequency of acute exacerbation, improving lung function, relieving clinical symptoms, and improving exercise endurance [6, 7, 17].This study shows that the intervention of integrated Chinese and Western medicine in AECOPD rats can not only reduce the pathological injury of alveoli, but also reduce the inflammatory infiltration of intestinal mucosa by increasing FVC, FEV0.3, and FEV0.3/FVC, as well as reducing CRP and SAA in serum. This evidence concerns the gene CRP and chronic obstructive pulmonary disease.