Insulin-like growth factor I and insulin are able to promote tumor development, long-term maintenance of high blood glucose levels increases the risk of prostate cancer recurrence, and prostate cancer patients with T2DM undergoing radical prostatectomy have a 50% increase in recurrence rate compared with prostate cancer patients with normal blood glucose values [21], suggesting that blood glucose levels may serve as a predictor of postoperative recurrence in T2DM patients with prostate cancer. Here, INS is linked to Familial prostate cancer.