Additionally, as homozygous loss-of-function mutations in DNAJC6 were previously identified in familial juvenile/early-onset PD [119–121], MOs harboring CRISPR/Cas9-mediated DNAJC6 mutations were generated and utilized for investigating the roles of DNAJC6 in PD pathogenesis [114]. This evidence concerns the gene DNAJC6 and Parkinson disease.