The first microcephalic cerebral organoids were derived from iPSCs of a microcephaly patient, harboring heterozygous truncation mutations in CDK5 regulatory subunit-associated protein 2 (CDK5RAP2), a component of the pericentriolar material (PCM) in centrosomes that regulates the organization of spindle microtubules [14]. The gene discussed is CDK5RAP2; the disease is microcephaly.