Mutations associated with type I/infantile onset GM1 gangliosidosis, for the most part, are located in the core protein region causing β-gal instability, whereas mutations associated with milder phenotypes, such as types II and III GM1 gangliosidosis, tend to be on the protein surface (Morita et al., 2009; Ohto et al., 2012; Rha et al., 2021). Here, GAL is linked to GM1 gangliosidosis.