As Supplementary Table 2 showed, we conducted an unbiased cytokine array analysis and found nine upregulated cytokines in ccRCC tissues with high fibrosis compared with those in tissues with low fibrosis (n = 11), including brevican, cerebral dopamine neurotrophic factor (CDNF), prolactin, GRO, IL-17, IL-6Rα, IL-7, IL-9, and presenilin 1 (p < 0.05). Here, PSEN1 is linked to nonpapillary renal cell carcinoma.