As Supplementary Table 2 showed, we conducted an unbiased cytokine array analysis and found nine upregulated cytokines in ccRCC tissues with high fibrosis compared with those in tissues with low fibrosis (n = 11), including brevican, cerebral dopamine neurotrophic factor (CDNF), prolactin, GRO, IL-17, IL-6Rα, IL-7, IL-9, and presenilin 1 (p < 0.05). The gene discussed is CXCL1; the disease is nonpapillary renal cell carcinoma.