CHST14 and Ehlers-Danlos syndrome: Malfait et al. (2010) proposed to unify EDS and the adducted thumb-clubfoot syndrome, caused by mutations in CHST14, as “musculocontractural EDS,” which was adopted in the 2017 International Classification of the Ehlers–Danlos syndromes as “EDS musculocontractural type 1” (Table 2; Malfait et al., 2017).