Interesting, the multivariable analysis suggested that the risk of lymph node metastasis is 2.5 times in CDH1 heterogeneous methylation group compare to CDH1 homogeneous methylation group (OR = 2.512, 95% CI 1.135, 5.557, P = 0.023, Table 4). This evidence concerns the gene CDH1 and metastatic malignant neoplasm in the lymph nodes.