Recent studies have shown that SLC7A11 expression is significantly lower in HPV-positive tumors than in HNSCC HPV-negative tumors, and that HNSCC with lower SLC7A11 expression is more sensitive to ferroptosis than HNSCC with higher SLC7A11 expression (Hémon et al., 2020). The gene discussed is SLC7A11; the disease is head and neck squamous cell carcinoma.