Many ovarian cancer patients with a strong family history had mutations of BRCA1/BRCA2, and a previous study demonstrated miR-146a can bind to the 3′-UTR region of the two genes and regulated their expression (Pastrello et al., 2010); patients who had polymorphism of hsa-mir-146a (rs2910164) may be diagnosed at a younger age than patients without a variant allele. The gene discussed is BRCA1; the disease is ovarian cancer.