RNA sequencing results revealed that disturbance of transcriptome was observed in shNTPCR ovarian cancer cells, and several miRNAs and TFs were predicted to be hub genes correlated with ovarian cancer, including hsa-miR-124-3p, hsa-miR-146a-5p, hsa-miR-30a-5p, EP300, GATA2, and STAT3. Here, EP300 is linked to ovarian carcinoma.