The pro-apoptotic Bcl-2 family promotes mitochondria-mediated apoptosis, and we show that ANT2 is linked to the apoptosis of PCa cells through regulation of Bcl-2, Bax, and caspase-3, which is consistent with a previous report (Sharaf el dein et al., 2011). Here, BCL2 is linked to posterior cortical atrophy.