GRN and behavioral variant of frontotemporal dementia: There is evidence of a significantly altered glial landscape in diseased brain regions (3–6), a consistent association of bvFTD with the HLA immune loci (7, 8) and disease-causative genes that are associated with inflammation in bvFTD (i.e. C9ORF72, PGRN, TREM2), as reviewed in detail elsewhere (9).