Treg cell-specific ectopic expression of Id2 (TetRId2EmGFPFoxp3YFP−Cre) resulted in reduced Foxp3+ Treg cell infiltration within tumor tissue as well as in tumor-draining lymph nodes, increased the expression of IL-17A within the CD4+Foxp3− tumor TILs and arrested tumor growth in B16F10 melanoma-bearing mice (98). This evidence concerns the gene CD4 and melanoma.