Multiple subsets of TH-like Tregs have been reported in cancer and autoimmunity settings expressing transcription factors and characteristic cytokines specific for T effector lineage, such as IFNγ+Tbet+CXCR3+ Th1-like Tregs, IL4+IL5+IL13+GATA3+ Th2-like Tregs, IL17A+RORt+ Th17-like Tregs, and CXCR5+Bcl6+ICOS+PD1+ follicular Tregs (TFR) (82–88). This evidence concerns the gene PDCD1 and cancer.