Up to date, the best characterized Th-like Treg subset in autoimmunity is the Th1-like Treg cells, with upregulated expression of transcription factor Tbet, chemokines CCR5 and CXCR3, stable Foxp3 expression due to highly demethylated TSDR region and increased production of IFN-γ cytokine. The gene discussed is TBX21; the disease is Autoimmunity.