The lower Treg cell numbers as well as the acquisition of pro-inflammatory functions of tumor-infiltrating FOXP3+ Treg cells drove to the remodeling of the TME by enhancing the recruitment and function of CD8+ and CD4+ effector T cells and protected mice from colon adenocarcinoma (MC-38), melanoma (B16-F10) and prostate cancer (TRAMP-C2) (95). The gene discussed is CD4; the disease is melanoma.