In this notion, impaired Foxp3 and Helios expression along with increased numbers of CD161+Th17 like CD45RA-Foxp3lo Treg cells was an early hallmark of multiple sclerosis (161), whereas epigenetic modification of Foxp3 through histone deacetylase mediated by TLR-2 stimulation induced IL-17 production in Treg cells isolated from multiple sclerosis patients (162). The gene discussed is KLRB1; the disease is multiple sclerosis.