For instance, IL-10 production by Treg cells decreases the interferon (IFN)-γ-dependent activation of antigen presenting cells (APCs), suppresses IFN-γ production in CD8+ cells and induces downregulation of major histocompatibility complex (MHC) II and CD86 in tumor-associated macrophages (18, 19). This evidence concerns the gene CD86 and neoplasm.